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The current study verified the effectiveness and safety of curcumenol, but there are still some issues and restrictions to our research. For efficiency, the systemic distribution of curcumenol right after intraperitoneal injection was not assessed, So there was a lack of direct proof the optimum focus of curcumenol attained the joint. In subsequent
Alternatively, we noticed a transparent reduction while in the drug potency when the PEGylation of DOTAP/cholesterol liposomes was raised from 5 mol% to 10 mol%. This is probably going because of the diminished mobile uptake in the liposomes, as PEGylation can impede the binding of cationic liposomes While using the cytoplasm membrane [eighteen]. T